Version 5.4
Homo sapiens Gene: GDI2
Summary
InnateDB Gene IDBG-49561.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GDI2
Gene Name GDP dissociation inhibitor 2
Synonyms HEL-S-46e; RABGDIB
Species Homo sapiens
Ensembl Gene ENSG00000057608
Encoded Proteins
IDBP-49563
GDP dissociation inhibitor 2
IDBP-49565
GDP dissociation inhibitor 2
IDBP-49573
GDP dissociation inhibitor 2
IDBP-363663
GDP dissociation inhibitor 2
IDBP-363666
GDP dissociation inhibitor 2
IDBP-363670
GDP dissociation inhibitor 2
IDBP-808524
GDP dissociation inhibitor 2
IDBP-808528
GDP dissociation inhibitor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:5765223-5842132
Strand Reverse strand
Band p15.1
Transcripts
ENST00000380191 ENSP00000369538
ENST00000380181 ENSP00000369528
ENST00000380127 ENSP00000369470
ENST00000447751 ENSP00000387565
ENST00000456041 ENSP00000401733
ENST00000418688 ENSP00000394177
ENST00000479928
ENST00000608581 ENSP00000476707
ENST00000609712 ENSP00000476832
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 32 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005093 Rab GDP-dissociation inhibitor activity
GO:0005097 Rab GTPase activator activity
GO:0005515 protein binding
GO:0031267 small GTPase binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0032851 positive regulation of Rab GTPase activity
GO:0050790 regulation of catalytic activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021218
View Gene Order
ENSBTAG00000005316
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.660588
RefSeq NM_001115156 NM_001494
HUGO
OMIM
CCDS CCDS44352 CCDS7071
HPRD 02863
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca