InnateDB Protein
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IDBP-50178.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RASSF2
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Protein Name
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Ras association (RalGDS/AF-6) domain family member 2
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Synonyms
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CENP-34; RASFADIN;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000368684
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InnateDB Gene
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IDBG-50172 (RASSF2)
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Protein Structure
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Function |
Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation. {ECO:0000269PubMed:12732644, ECO:0000269PubMed:16012945, ECO:0000269PubMed:19525978}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=Translocates to the cytoplasm in the presence of STK3/MST2 AND STK4/MST1.
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Disease Associations |
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Tissue Specificity |
Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines. {ECO:0000269PubMed:12732644}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
46
[view]
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Protein-Protein |
46
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000159
Ras-association
IPR011524
SARAH domain
IPR029071
Ubiquitin-related domain
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PFAM |
PF00788
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PRINTS |
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PIRSF |
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SMART |
SM00314
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TIGRFAMs |
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Modification |
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SwissProt |
P50749
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PhosphoSite |
PhosphoSite-P50749
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9770
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UniGene |
Hs.631504
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RefSeq |
NP_739580
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HUGO |
HGNC:9883
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OMIM |
609492
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CCDS |
CCDS13083
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HPRD |
15218
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IMGT |
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EMBL |
AK222650
AK291458
AL133354
AY154470
AY154472
BC117118
BC117120
CH471133
CR627436
D79990
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GenPept |
AAI17119
AAI17121
AAN59975
AAN59977
BAA11485
BAD96370
BAF84147
CAC34362
CAH10522
EAX10445
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