InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FADS1

Summary

InnateDB Protein

IDBP-50480.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FADS1

Protein Name

fatty acid desaturase 1

Synonyms

D5D; FADS6; FADSD5; LLCDL1; TU12;

Species

Homo sapiens

Ensembl Protein

ENSP00000322229

InnateDB Gene

IDBG-50478 (FADS1)

Protein Structure

UniProt Annotation

Function

Isoform 2 does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity (By similarity). Isoform 1 is a component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3), respectively. {ECO:0000250, ECO:0000269PubMed:10601301, ECO:0000269PubMed:10769175}.

Subcellular Localization

Isoform 1: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Mitochondrion {ECO:0000269PubMed:22619218}.Isoform 2: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed, with highest levels in liver, brain, adrenal gland and heart. Highly expressed in fetal liver and brain. {ECO:0000269PubMed:10601301, ECO:0000269PubMed:10769175, ECO:0000269PubMed:10860662}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000248	C-5 sterol desaturase activity
GO:0005506	iron ion binding
GO:0016491	oxidoreductase activity
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
GO:0020037	heme binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006629	lipid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0006636	unsaturated fatty acid biosynthetic process
GO:0007267	cell-cell signaling
GO:0007568	aging
GO:0007584	response to nutrient
GO:0008654	phospholipid biosynthetic process
GO:0009267	cellular response to starvation
GO:0009744	response to sucrose stimulus
GO:0010033	response to organic substance
GO:0014070	response to organic cyclic compound
GO:0019369	arachidonic acid metabolic process
GO:0032868	response to insulin
GO:0033189	response to vitamin A
GO:0033559	unsaturated fatty acid metabolic process
GO:0035900	response to isolation stress
GO:0036109	alpha-linolenic acid metabolic process
GO:0043651	linoleic acid metabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045595	regulation of cell differentiation
GO:0046456	icosanoid biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle