InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STAT5B

Summary

InnateDB Protein

IDBP-50534.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STAT5B

Protein Name

signal transducer and activator of transcription 5B

Synonyms

STAT5;

Species

Homo sapiens

Ensembl Protein

ENSP00000293328

InnateDB Gene

IDBG-50532 (STAT5B)

Protein Structure

UniProt Annotation

Function

Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. {ECO:0000269PubMed:11773439}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocated into the nucleus in response to phosphorylation. {ECO:0000250}.

Disease Associations

Growth hormone insensitivity with immunodeficiency (GHII) [MIM:245590]: A disease characterized by short stature, growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, resistance to hexogeneous growth hormone therapy, and recurrent infections. {ECO:0000269PubMed:13679528, ECO:0000269PubMed:15827093, ECO:0000269PubMed:22419735}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	79 [view]
Protein-Protein	59 [view]
Protein-DNA	20 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019903	protein phosphatase binding
GO:0035259	glucocorticoid receptor binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000255	allantoin metabolic process
GO:0001553	luteinization
GO:0001666	response to hypoxia
GO:0001779	natural killer cell differentiation
GO:0001889	liver development
GO:0006101	citrate metabolic process
GO:0006103	2-oxoglutarate metabolic process
GO:0006105	succinate metabolic process
GO:0006107	oxaloacetate metabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006549	isoleucine metabolic process
GO:0006573	valine metabolic process
GO:0006600	creatine metabolic process
GO:0006631	fatty acid metabolic process
GO:0006953	acute-phase response
GO:0007165	signal transduction
GO:0007259	JAK-STAT cascade
GO:0007548	sex differentiation
GO:0007565	female pregnancy
GO:0007595	lactation
GO:0008284	positive regulation of cell proliferation
GO:0019218	regulation of steroid metabolic process
GO:0019221	cytokine-mediated signaling pathway
GO:0019530	taurine metabolic process
GO:0019915	lipid storage
GO:0030155	regulation of cell adhesion
GO:0030856	regulation of epithelial cell differentiation
GO:0032355	response to estradiol
GO:0032496	response to lipopolysaccharide
GO:0032819	positive regulation of natural killer cell proliferation
GO:0032825	positive regulation of natural killer cell differentiation
GO:0032870	cellular response to hormone stimulus
GO:0033077	T cell differentiation in thymus
GO:0038161	prolactin signaling pathway
GO:0040014	regulation of multicellular organism growth
GO:0040018	positive regulation of multicellular organism growth
GO:0042104	positive regulation of activated T cell proliferation
GO:0042448	progesterone metabolic process
GO:0043029	T cell homeostasis
GO:0043066	negative regulation of apoptotic process
GO:0043434	response to peptide hormone
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0045579	positive regulation of B cell differentiation
GO:0045588	positive regulation of gamma-delta T cell differentiation
GO:0045621	positive regulation of lymphocyte differentiation
GO:0045647	negative regulation of erythrocyte differentiation
GO:0045931	positive regulation of mitotic cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0046449	creatinine metabolic process
GO:0046543	development of secondary female sexual characteristics
GO:0046544	development of secondary male sexual characteristics
GO:0048541	Peyer's patch development
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050729	positive regulation of inflammatory response
GO:0051272	positive regulation of cellular component movement
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070669	response to interleukin-2
GO:0070670	response to interleukin-4
GO:0070672	response to interleukin-15
GO:0071363	cellular response to growth factor stimulus
GO:0071364	cellular response to epidermal growth factor stimulus

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000980 SH2 domain
IPR008967 p53-like transcription factor, DNA-binding
IPR013799 STAT transcription factor, protein interaction
IPR013800 STAT transcription factor, all-alpha
IPR013801 STAT transcription factor, DNA-binding
IPR015988 STAT transcription factor, coiled coil

PFAM

PF00017
PF14633
PF02865
PF01017
PF02864

PRINTS

PR00401

PIRSF

SMART

SM00252
SM00964

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt