InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STAT5A

Summary

InnateDB Protein

IDBP-50627.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STAT5A

Protein Name

signal transducer and activator of transcription 5A

Synonyms

MGF; STAT5;

Species

Homo sapiens

Ensembl Protein

ENSP00000341208

InnateDB Gene

IDBG-50625 (STAT5A)

Protein Structure

UniProt Annotation

Function

Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. {ECO:0000269PubMed:11773439, ECO:0000269PubMed:15534001}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15534001}. Nucleus {ECO:0000269PubMed:15534001}. Note=Translocated into the nucleus in response to phosphorylation.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 123 experimentally validated interaction(s) in this database.

Experimentally validated
Total	123 [view]
Protein-Protein	94 [view]
Protein-DNA	29 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019903	protein phosphatase binding

Biological Process

GO:0000255	allantoin metabolic process
GO:0001553	luteinization
GO:0001779	natural killer cell differentiation
GO:0006101	citrate metabolic process
GO:0006103	2-oxoglutarate metabolic process
GO:0006105	succinate metabolic process
GO:0006107	oxaloacetate metabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006549	isoleucine metabolic process
GO:0006573	valine metabolic process
GO:0006600	creatine metabolic process
GO:0006631	fatty acid metabolic process
GO:0007165	signal transduction
GO:0007259	JAK-STAT cascade
GO:0007565	female pregnancy
GO:0007595	lactation
GO:0008284	positive regulation of cell proliferation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019218	regulation of steroid metabolic process
GO:0019221	cytokine-mediated signaling pathway
GO:0019530	taurine metabolic process
GO:0019915	lipid storage
GO:0030155	regulation of cell adhesion
GO:0030856	regulation of epithelial cell differentiation
GO:0030879	mammary gland development
GO:0032825	positive regulation of natural killer cell differentiation
GO:0033026	negative regulation of mast cell apoptotic process
GO:0033077	T cell differentiation in thymus
GO:0038161	prolactin signaling pathway
GO:0040014	regulation of multicellular organism growth
GO:0040018	positive regulation of multicellular organism growth
GO:0042104	positive regulation of activated T cell proliferation
GO:0043029	T cell homeostasis
GO:0043066	negative regulation of apoptotic process
GO:0043434	response to peptide hormone
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045579	positive regulation of B cell differentiation
GO:0045588	positive regulation of gamma-delta T cell differentiation
GO:0045621	positive regulation of lymphocyte differentiation
GO:0045647	negative regulation of erythrocyte differentiation
GO:0045931	positive regulation of mitotic cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0046449	creatinine metabolic process
GO:0046543	development of secondary female sexual characteristics
GO:0046544	development of secondary male sexual characteristics
GO:0048541	Peyer's patch development
GO:0050729	positive regulation of inflammatory response
GO:0060376	positive regulation of mast cell differentiation
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060740	prostate gland epithelium morphogenesis
GO:0060742	epithelial cell differentiation involved in prostate gland development
GO:0061180	mammary gland epithelium development
GO:0070668	positive regulation of mast cell proliferation
GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000980 SH2 domain
IPR008967 p53-like transcription factor, DNA-binding
IPR013799 STAT transcription factor, protein interaction
IPR013800 STAT transcription factor, all-alpha
IPR013801 STAT transcription factor, DNA-binding
IPR015988 STAT transcription factor, coiled coil

PFAM

PF00017
PF14633
PF02865
PF01017
PF02864

PRINTS

PR00401

PIRSF

SMART

SM00252
SM00964

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt