Homo sapiens Gene: STAT5A
Summary
InnateDB Gene IDBG-50625.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STAT5A
Gene Name signal transducer and activator of transcription 5A
Synonyms MGF; STAT5;
Species Homo sapiens
Ensembl Gene ENSG00000126561
Encoded Proteins
signal transducer and activator of transcription 5A
signal transducer and activator of transcription 5A
signal transducer and activator of transcription 5A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IL-2 and IL-7 induced heterodimerization of STAT5 isoforms in human peripheral blood T lymphoblast
Entrez Gene
Summary The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:42287547-42311943
Strand Forward strand
Band q21.2
Transcripts
ENST00000345506 ENSP00000341208
ENST00000444283 ENSP00000407327
ENST00000469124
ENST00000478897
ENST00000479417
ENST00000468096
ENST00000546010 ENSP00000443107
ENST00000591556
ENST00000587646 ENSP00000466320
ENST00000590726 ENSP00000464730
ENST00000588868 ENSP00000465437
ENST00000590949 ENSP00000468749
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 123 experimentally validated interaction(s) in this database.
Experimentally validated
Total 123 [view]
Protein-Protein 94 [view]
Protein-DNA 29 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0019903 protein phosphatase binding
Biological Process
GO:0000255 allantoin metabolic process
GO:0001553 luteinization
GO:0001779 natural killer cell differentiation
GO:0006101 citrate metabolic process
GO:0006103 2-oxoglutarate metabolic process
GO:0006105 succinate metabolic process
GO:0006107 oxaloacetate metabolic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006549 isoleucine metabolic process
GO:0006573 valine metabolic process
GO:0006600 creatine metabolic process
GO:0006631 fatty acid metabolic process
GO:0007165 signal transduction
GO:0007259 JAK-STAT cascade
GO:0007565 female pregnancy
GO:0007595 lactation
GO:0008284 positive regulation of cell proliferation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019218 regulation of steroid metabolic process
GO:0019221 cytokine-mediated signaling pathway
GO:0019530 taurine metabolic process
GO:0019915 lipid storage
GO:0030155 regulation of cell adhesion
GO:0030856 regulation of epithelial cell differentiation
GO:0030879 mammary gland development
GO:0032825 positive regulation of natural killer cell differentiation
GO:0033026 negative regulation of mast cell apoptotic process
GO:0033077 T cell differentiation in thymus
GO:0038161 prolactin signaling pathway
GO:0040014 regulation of multicellular organism growth
GO:0040018 positive regulation of multicellular organism growth
GO:0042104 positive regulation of activated T cell proliferation
GO:0043029 T cell homeostasis
GO:0043066 negative regulation of apoptotic process
GO:0043434 response to peptide hormone
GO:0045086 positive regulation of interleukin-2 biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045579 positive regulation of B cell differentiation
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0045621 positive regulation of lymphocyte differentiation
GO:0045647 negative regulation of erythrocyte differentiation
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0046449 creatinine metabolic process
GO:0046543 development of secondary female sexual characteristics
GO:0046544 development of secondary male sexual characteristics
GO:0048541 Peyer's patch development
GO:0050729 positive regulation of inflammatory response
GO:0060376 positive regulation of mast cell differentiation
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060740 prostate gland epithelium morphogenesis
GO:0060742 epithelial cell differentiation involved in prostate gland development
GO:0061180 mammary gland epithelium development
GO:0070668 positive regulation of mast cell proliferation
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
EGFR1 pathway
KitReceptor pathway
TNFalpha pathway
TCR pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL5 pathway
IL6 pathway
IL-7 pathway
IL9 pathway
Leptin pathway
TSLP pathway
Prolactin pathway
REACTOME
Signaling by FGFR in disease pathway
Signaling by FGFR mutants pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Cytokine Signaling in Immune system pathway
Signaling by ERBB4 pathway
Signaling by FGFR1 mutants pathway
Signaling by SCF-KIT pathway
Signal Transduction pathway
Prolactin receptor signaling pathway
Immune System pathway
Downstream signal transduction pathway
Interleukin-2 signaling pathway
Growth hormone receptor signaling pathway
Signaling by Interleukins pathway
Interleukin-7 signaling pathway
Signaling by PDGF pathway
Nuclear signaling by ERBB4 pathway
Signaling by FGFR1 fusion mutants pathway
Disease pathway
Signaling by Leptin pathway
KEGG
ErbB signaling pathway pathway
Jak-STAT signaling pathway pathway
Pathways in cancer pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
INOH
PDGF signaling pathway pathway
IL-7 signaling pathway
IL-3 signaling pathway
JAK STAT pathway and regulation pathway
IL-2 signaling pathway
Growth hormone signaling pathway
EPO signaling pathway pathway
IL-5 signaling pathway
PID BIOCARTA
Inhibition of cellular proliferation by gleevec [Biocarta view]
Il 2 signaling pathway [Biocarta view]
Il 3 signaling pathway [Biocarta view]
Il-2 receptor beta chain in t cell activation [Biocarta view]
Epo signaling pathway [Biocarta view]
Growth hormone signaling pathway [Biocarta view]
Il22 soluble receptor signaling pathway [Biocarta view]
Tpo signaling pathway [Biocarta view]
Bioactive peptide induced signaling pathway [Biocarta view]
Il-7 signal transduction [Biocarta view]
PID NCI
Trk receptor signaling mediated by PI3K and PLC-gamma
CD40/CD40L signaling
Validated nuclear estrogen receptor alpha network
ErbB4 signaling events
IL27-mediated signaling events
IL12-mediated signaling events
Signaling events mediated by PTP1B
RAC1 signaling pathway
Angiopoietin receptor Tie2-mediated signaling
Signaling events mediated by Stem cell factor receptor (c-Kit)
Signaling events mediated by TCPTP
IL23-mediated signaling events
Cross-References
SwissProt
TrEMBL C9JVV6
UniProt Splice Variant
Entrez Gene 6776
UniGene Hs.437058
RefSeq NM_003152 NM_001288718 NM_001288719 NM_001288720
HUGO HGNC:11366
OMIM 601511
CCDS CCDS11424 CCDS74067 CCDS74066
HPRD 03301
IMGT
EMBL AC087691 AC099811
GenPept
RNA Seq Atlas 6776