InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DRD3

Summary

InnateDB Protein

IDBP-50678.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DRD3

Protein Name

dopamine receptor D3

Synonyms

D3DR; ETM1; FET1;

Species

Homo sapiens

Ensembl Protein

ENSP00000373169

InnateDB Gene

IDBG-50672 (DRD3)

Protein Structure

UniProt Annotation

Function

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. {ECO:0000269PubMed:19520868}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:19520868}; Multi-pass membrane protein {ECO:0000269PubMed:19520868}. Note=Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co- localize in lipid rafts of renal proximal tubule cells.

Disease Associations

Tremor, hereditary essential 1 (ETM1) [MIM:190300]: A common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. {ECO:0000269PubMed:16650084, ECO:0000269PubMed:16809426}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0004930	G-protein coupled receptor activity
GO:0004952	dopamine receptor activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0019904	protein domain specific binding
GO:0031748	D1 dopamine receptor binding
GO:0035240	dopamine binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001963	synaptic transmission, dopaminergic
GO:0001975	response to amphetamine
GO:0002016	regulation of blood volume by renin-angiotensin
GO:0002031	G-protein coupled receptor internalization
GO:0006874	cellular calcium ion homeostasis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007212	dopamine receptor signaling pathway
GO:0007611	learning or memory
GO:0007612	learning
GO:0007626	locomotory behavior
GO:0008284	positive regulation of cell proliferation
GO:0008542	visual learning
GO:0014059	regulation of dopamine secretion
GO:0019216	regulation of lipid metabolic process
GO:0030814	regulation of cAMP metabolic process
GO:0032416	negative regulation of sodium:hydrogen antiporter activity
GO:0032467	positive regulation of cytokinesis
GO:0032922	circadian regulation of gene expression
GO:0034776	response to histamine
GO:0035176	social behavior
GO:0035483	gastric emptying
GO:0035815	positive regulation of renal sodium excretion
GO:0040012	regulation of locomotion
GO:0040014	regulation of multicellular organism growth
GO:0042220	response to cocaine
GO:0042417	dopamine metabolic process
GO:0042493	response to drug
GO:0043278	response to morphine
GO:0045187	regulation of circadian sleep/wake cycle, sleep
GO:0045471	response to ethanol
GO:0045776	negative regulation of blood pressure
GO:0045840	positive regulation of mitosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046717	acid secretion
GO:0048148	behavioral response to cocaine
GO:0048715	negative regulation of oligodendrocyte differentiation
GO:0050482	arachidonic acid secretion
GO:0050709	negative regulation of protein secretion
GO:0050883	musculoskeletal movement, spinal reflex action
GO:0051584	regulation of dopamine uptake involved in synaptic transmission
GO:0051898	negative regulation of protein kinase B signaling
GO:0060134	prepulse inhibition
GO:0060160	negative regulation of dopamine receptor signaling pathway
GO:0060161	positive regulation of dopamine receptor signaling pathway
GO:0090325	regulation of locomotion involved in locomotory behavior

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030139	endocytic vesicle
GO:0042995	cell projection
GO:0045177	apical part of cell

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000929 Dopamine receptor family
IPR001620 Dopamine D3 receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00242
PR00568

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P35462