Homo sapiens Gene: DRD3
Summary
InnateDB Gene IDBG-50672.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DRD3
Gene Name dopamine receptor D3
Synonyms D3DR; ETM1; FET1;
Species Homo sapiens
Ensembl Gene ENSG00000151577
Encoded Proteins
dopamine receptor D3
dopamine receptor D3
dopamine receptor D3
dopamine receptor D3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:114128652-114199407
Strand Reverse strand
Band q13.31
Transcripts
ENST00000295881 ENSP00000295881
ENST00000383673 ENSP00000373169
ENST00000460779 ENSP00000419402
ENST00000467632 ENSP00000420662
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0004930 G-protein coupled receptor activity
GO:0004952 dopamine receptor activity
GO:0005515 protein binding
GO:0008144 drug binding
GO:0019904 protein domain specific binding
GO:0031748 D1 dopamine receptor binding
GO:0035240 dopamine binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001963 synaptic transmission, dopaminergic
GO:0001975 response to amphetamine
GO:0002016 regulation of blood volume by renin-angiotensin
GO:0002031 G-protein coupled receptor internalization
GO:0006874 cellular calcium ion homeostasis
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007212 dopamine receptor signaling pathway
GO:0007611 learning or memory
GO:0007612 learning
GO:0007626 locomotory behavior
GO:0008284 positive regulation of cell proliferation
GO:0008542 visual learning
GO:0014059 regulation of dopamine secretion
GO:0019216 regulation of lipid metabolic process
GO:0030814 regulation of cAMP metabolic process
GO:0032416 negative regulation of sodium:hydrogen antiporter activity
GO:0032467 positive regulation of cytokinesis
GO:0032922 circadian regulation of gene expression
GO:0034776 response to histamine
GO:0035176 social behavior
GO:0035483 gastric emptying
GO:0035815 positive regulation of renal sodium excretion
GO:0040012 regulation of locomotion
GO:0040014 regulation of multicellular organism growth
GO:0042220 response to cocaine
GO:0042417 dopamine metabolic process
GO:0042493 response to drug
GO:0043278 response to morphine
GO:0045187 regulation of circadian sleep/wake cycle, sleep
GO:0045471 response to ethanol
GO:0045776 negative regulation of blood pressure
GO:0045840 positive regulation of mitosis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046717 acid secretion
GO:0048148 behavioral response to cocaine
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0050482 arachidonic acid secretion
GO:0050709 negative regulation of protein secretion
GO:0050883 musculoskeletal movement, spinal reflex action
GO:0051584 regulation of dopamine uptake involved in synaptic transmission
GO:0051898 negative regulation of protein kinase B signaling
GO:0060134 prepulse inhibition
GO:0060160 negative regulation of dopamine receptor signaling pathway
GO:0060161 positive regulation of dopamine receptor signaling pathway
GO:0090325 regulation of locomotion involved in locomotory behavior
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030139 endocytic vesicle
GO:0042995 cell projection
GO:0045177 apical part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Amine ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
Dopamine receptors pathway
GPCR ligand binding pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.121478
RefSeq NM_000796 NM_001282563 NM_001290809 NM_033663 XM_006713522
HUGO
OMIM
CCDS CCDS2978 CCDS33829
HPRD 00540
IMGT
EMBL
GenPept
RNA Seq Atlas