InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PFKFB3

Summary

InnateDB Protein

IDBP-50938.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PFKFB3

Protein Name

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

Synonyms

IPFK2; PFK2;

Species

Homo sapiens

Ensembl Protein

ENSP00000353712

InnateDB Gene

IDBG-50922 (PFKFB3)

Protein Structure

UniProt Annotation

Function

Synthesis and degradation of fructose 2,6-bisphosphate.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003873	6-phosphofructo-2-kinase activity
GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005524	ATP binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006000	fructose metabolic process
GO:0006003	fructose 2,6-bisphosphate metabolic process
GO:0006006	glucose metabolic process
GO:0006096	glycolytic process
GO:0016311	dephosphorylation
GO:0044281	small molecule metabolic process
GO:0046835	carbohydrate phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR003094 Fructose-2,6-bisphosphatase
IPR013078 Histidine phosphatase superfamily, clade-1
IPR013079 6-phosphofructo-2-kinase
IPR013641 Chromatin associated protein KTI12
IPR016260 Bifunctional 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphate 2-phosphatase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029033 Histidine phosphatase superfamily

PFAM

PF00300
PF01591
PF08433

PRINTS

PR00991

PIRSF

PIRSF000709

SMART

SM00855

TIGRFAMs

Post-translational Modifications

Modification

Cross-References