InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FOXA1

Summary

InnateDB Protein

IDBP-5106.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOXA1

Protein Name

forkhead box A1

Synonyms

HNF3A; TCF3A;

Species

Homo sapiens

Ensembl Protein

ENSP00000250448

InnateDB Gene

IDBG-5104 (FOXA1)

Protein Structure

UniProt Annotation

Function

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis- acting regulatory regions of these genes. Involved in glucose homeostasis. {ECO:0000250, ECO:0000269PubMed:16087863, ECO:0000269PubMed:16331276, ECO:0000269PubMed:18358809, ECO:0000269PubMed:19127412, ECO:0000269PubMed:19917725}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00089, ECO:0000269PubMed:15987773, ECO:0000269PubMed:16331276}.

Disease Associations

Tissue Specificity

Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas. {ECO:0000269PubMed:12234996, ECO:0000269PubMed:15987773, ECO:0000269PubMed:16331276}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	11 [view]
Protein-DNA	12 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0019904	protein domain specific binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006338	chromatin remodeling
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0010468	regulation of gene expression
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0021904	dorsal/ventral neural tube patterning
GO:0030324	lung development
GO:0032355	response to estradiol
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway
GO:0035239	tube morphogenesis
GO:0042445	hormone metabolic process
GO:0042593	glucose homeostasis
GO:0045087	innate immune response
GO:0045666	positive regulation of neuron differentiation
GO:0045880	positive regulation of smoothened signaling pathway
GO:0045931	positive regulation of mitotic cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0048665	neuron fate specification
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051726	regulation of cell cycle
GO:0060441	epithelial tube branching involved in lung morphogenesis
GO:0060487	lung epithelial cell differentiation
GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0060738	epithelial-mesenchymal signaling involved in prostate gland development
GO:0060740	prostate gland epithelium morphogenesis
GO:0060741	prostate gland stromal morphogenesis
GO:0060743	epithelial cell maturation involved in prostate gland development
GO:0061448	connective tissue development
GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin