InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FBXO11

Summary

InnateDB Protein

IDBP-51125.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXO11

Protein Name

F-box protein 11

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000323822

InnateDB Gene

IDBG-51123 (FBXO11)

Protein Structure

UniProt Annotation

Function

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2 and BCL6. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53. {ECO:0000269PubMed:17098746, ECO:0000269PubMed:22113614, ECO:0000269PubMed:23478441, ECO:0000269PubMed:23478445, ECO:0000269PubMed:23892434}.

Subcellular Localization

Nucleus. Chromosome.

Disease Associations

Note=Defects in FBXO11 may be a cause of diffuse large B- cell lymphoma by allowing the accumulation of BCL6, an oncoprotein that has a critical role in lymphomas. {ECO:0000269PubMed:22113614}.

Tissue Specificity

Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes. {ECO:0000269PubMed:11775060}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016274	protein-arginine N-methyltransferase activity

Biological Process

GO:0006464	cellular protein modification process
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016567	protein ubiquitination
GO:0035246	peptidyl-arginine N-methylation

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005694	chromosome
GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001810 F-box domain
IPR006626 Parallel beta-helix repeat
IPR006633 Carbohydrate-binding/sugar hydrolysis domain
IPR011050 Pectin lyase fold/virulence factor
IPR022441 Parallel beta-helix repeat-2

PFAM

PF00646
PF12937
PF13013

PRINTS

PIRSF

SMART

SM00256
SM00710
SM00722

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q86XK2