InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BLVRB

Summary

InnateDB Protein

IDBP-51568.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BLVRB

Protein Name

biliverdin reductase B (flavin reductase (NADPH))

Synonyms

BVRB; FLR; HEL-S-10; SDR43U1;

Species

Homo sapiens

Ensembl Protein

ENSP00000263368

InnateDB Gene

IDBG-51566 (BLVRB)

Protein Structure

UniProt Annotation

Function

Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. {ECO:0000269PubMed:10620517}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:7929092}.

Disease Associations

Tissue Specificity

Predominantly expressed in liver and erythrocytes. At lower levels in heart, lung, adrenal gland and cerebrum. {ECO:0000269PubMed:7929092}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	6 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0004074	biliverdin reductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042602	riboflavin reductase (NADPH) activity
GO:0050662	coenzyme binding

Biological Process

GO:0006694	steroid biosynthetic process
GO:0006778	porphyrin-containing compound metabolic process
GO:0042167	heme catabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process