Version 5.4
Homo sapiens Gene: BLVRB
Summary
InnateDB Gene IDBG-51566.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BLVRB
Gene Name biliverdin reductase B (flavin reductase (NADPH))
Synonyms BVRB; FLR; HEL-S-10; SDR43U1
Species Homo sapiens
Ensembl Gene ENSG00000090013
Encoded Proteins
IDBP-51568
biliverdin reductase B (flavin reductase (NADPH))
IDBP-762873
IDBP-760659
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B (EC 1.3.1.24).[supplied by OMIM, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:40447789-40465840
Strand Reverse strand
Band q13.2
Transcripts
ENST00000263368 ENSP00000263368
ENST00000597870 ENSP00000470619
ENST00000595483 ENSP00000471720
ENST00000601346
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 6 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0004074 biliverdin reductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042602 riboflavin reductase (NADPH) activity
GO:0050662 coenzyme binding
Biological Process
GO:0006694 steroid biosynthetic process
GO:0006778 porphyrin-containing compound metabolic process
GO:0042167 heme catabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040466
View Gene Order
ENSBTAG00000010508
Not yet available
Pathways
NETPATH
REACTOME
REACT_22297
Heme degradation pathway
REACT_9431
Metabolism of porphyrins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00740
Riboflavin metabolism pathway
hsa00860
Porphyrin and chlorophyll metabolism pathway
INOH
PID NCI
Cross-References
SwissProt P30043
TrEMBL V9HWI1
UniProt Splice Variant
Entrez Gene 645
UniGene
RefSeq NM_000713
HUGO HGNC:1063
OMIM 600941
CCDS CCDS33029
HPRD 02967
IMGT
EMBL AC010271 AK312137 AY340485 BC109371 CH471126 D26308 D32143 EU794593
GenPept AAI09372 AAP88933 ACJ13647 BAA05370 BAA06874 BAG35073 EAW56969
RNA Seq Atlas 645

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca