Homo sapiens Gene: BLVRB
Summary
InnateDB Gene IDBG-51566.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BLVRB
Gene Name biliverdin reductase B (flavin reductase (NADPH))
Synonyms BVRB; FLR; HEL-S-10; SDR43U1;
Species Homo sapiens
Ensembl Gene ENSG00000090013
Encoded Proteins
biliverdin reductase B (flavin reductase (NADPH))
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B (EC 1.3.1.24).[supplied by OMIM, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:40447789-40465840
Strand Reverse strand
Band q13.2
Transcripts
ENST00000263368 ENSP00000263368
ENST00000597870 ENSP00000470619
ENST00000595483 ENSP00000471720
ENST00000601346
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 6 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0004074 biliverdin reductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042602 riboflavin reductase (NADPH) activity
GO:0050662 coenzyme binding
Biological Process
GO:0006694 steroid biosynthetic process
GO:0006778 porphyrin-containing compound metabolic process
GO:0042167 heme catabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Heme degradation pathway
Metabolism of porphyrins pathway
Metabolism pathway
KEGG
Riboflavin metabolism pathway
Porphyrin and chlorophyll metabolism pathway
INOH
PID BIOCARTA
Il-10 anti-inflammatory signaling pathway [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL M0QZL1
UniProt Splice Variant
Entrez Gene 645
UniGene
RefSeq NM_000713
HUGO HGNC:1063
OMIM 600941
CCDS CCDS33029
HPRD 02967
IMGT
EMBL AC010271 AC020929
GenPept
RNA Seq Atlas 645