InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FGD6

Summary

InnateDB Protein

IDBP-51606.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGD6

Protein Name

FYVE, RhoGEF and PH domain containing 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000344446

InnateDB Gene

IDBG-51604 (FGD6)

Protein Structure

UniProt Annotation

Function

May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0031267	small GTPase binding
GO:0046872	metal ion binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0008360	regulation of cell shape
GO:0030036	actin cytoskeleton organization
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043088	regulation of Cdc42 GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0046847	filopodium assembly