Version 5.4
Homo sapiens Gene: FGD6
Summary
InnateDB Gene IDBG-51604.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGD6
Gene Name FYVE, RhoGEF and PH domain containing 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000180263
Encoded Proteins
IDBP-51606
FYVE, RhoGEF and PH domain containing 6
IDBP-381222
FYVE, RhoGEF and PH domain containing 6
IDBP-585726
FYVE, RhoGEF and PH domain containing 6
IDBP-591373
FYVE, RhoGEF and PH domain containing 6
IDBP-589277
FYVE, RhoGEF and PH domain containing 6
IDBP-588566
FYVE, RhoGEF and PH domain containing 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 12:95076749-95217482
Strand Reverse strand
Band q22
Transcripts
ENST00000343958 ENSP00000344446
ENST00000451107 ENSP00000408291
ENST00000548069 ENSP00000448350
ENST00000546711 ENSP00000450342
ENST00000551521 ENSP00000450240
ENST00000549499 ENSP00000449005
ENST00000550368
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0031267 small GTPase binding
GO:0046872 metal ion binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0008360 regulation of cell shape
GO:0030036 actin cytoskeleton organization
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0043088 regulation of Cdc42 GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0046847 filopodium assembly
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005856 cytoskeleton
GO:0030027 lamellipodium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020021
View Gene Order
ENSBTAG00000014030
Not yet available
Cross-References
SwissProt
TrEMBL F8VWT6
UniProt Splice Variant
Entrez Gene 55785
UniGene Hs.506381 Hs.606337 Hs.707232
RefSeq NM_018351
HUGO HGNC:21740
OMIM 613520
CCDS CCDS31878
HPRD 16892
IMGT
EMBL AC011598 AC126615 AC127165
GenPept
RNA Seq Atlas 55785

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca