InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FBXO7

Summary

InnateDB Protein

IDBP-5166.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXO7

Protein Name

F-box protein 7

Synonyms

FBX; FBX07; FBX7; PARK15; PKPS;

Species

Homo sapiens

Ensembl Protein

ENSP00000266087

InnateDB Gene

IDBG-5164 (FBXO7)

Protein Structure

UniProt Annotation

Function

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PARK2 to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination. {ECO:0000269PubMed:15145941, ECO:0000269PubMed:16510124, ECO:0000269PubMed:23933751}.

Subcellular Localization

Cytoplasm. Nucleus. Mitochondrion. Cytoplasm, cytosol. Note=Predominantly cytoplasmic. A minor proportion is detected in the nucleus. Relocates from the cytosol to depolarized mitochondria.

Disease Associations

Parkinson disease 15 (PARK15) [MIM:260300]: A neurodegenerative disorder characterized by parkinsonian and pyramidal signs. Clinical manifestations include tremor, bradykinesia, rigidity, postural instability, spasticity, mainly in the lower limbs, and hyperreflexia. {ECO:0000269PubMed:18513678}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000422	mitochondrion degradation
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006626	protein targeting to mitochondrion
GO:0008219	cell death
GO:0016567	protein ubiquitination
GO:0031647	regulation of protein stability
GO:0045620	negative regulation of lymphocyte differentiation
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle