Version 5.4
Homo sapiens Gene: FBXO7
Summary
InnateDB Gene IDBG-5164.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO7
Gene Name F-box protein 7
Synonyms FBX; FBX07; FBX7; PARK15; PKPS
Species Homo sapiens
Ensembl Gene ENSG00000100225
Encoded Proteins
IDBP-5166
F-box protein 7
IDBP-235369
F-box protein 7
IDBP-373726
F-box protein 7
IDBP-373747
F-box protein 7
IDBP-373756
F-box protein 7
IDBP-373761
F-box protein 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:32474676-32498829
Strand Forward strand
Band q12.3
Transcripts
ENST00000266087 ENSP00000266087
ENST00000397426 ENSP00000380571
ENST00000420700 ENSP00000406155
ENST00000425028 ENSP00000395823
ENST00000452138 ENSP00000388547
ENST00000444207 ENSP00000404388
ENST00000492535
ENST00000465418
ENST00000484607
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 31 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000422 mitochondrion degradation
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006626 protein targeting to mitochondrion
GO:0008219 cell death
GO:0016567 protein ubiquitination
GO:0031647 regulation of protein stability
GO:0045620 negative regulation of lymphocyte differentiation
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001786
View Gene Order
ENSBTAG00000020634
Not yet available
Cross-References
SwissProt
TrEMBL A2A282
UniProt Splice Variant
Entrez Gene 25793
UniGene Hs.5912 Hs.628106 Hs.736991
RefSeq NM_001033024 NM_001257990 NM_012179
HUGO HGNC:13586
OMIM 605648
CCDS CCDS13907 CCDS58806
HPRD 07292
IMGT
EMBL AL021937 AL035068 Z71183
GenPept
RNA Seq Atlas 25793

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca