InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRMT6

Summary

InnateDB Protein

IDBP-51863.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRMT6

Protein Name

tRNA methyltransferase 6 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000203001

InnateDB Gene

IDBG-51859 (TRMT6)

Protein Structure

UniProt Annotation

Function

Substrate-binding subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. {ECO:0000269PubMed:16043508}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain, liver, testis and ovary. {ECO:0000269PubMed:10574461}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003743	translation initiation factor activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006413	translational initiation
GO:0006446	regulation of translational initiation
GO:0008033	tRNA processing

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR007316 Eukaryotic initiation factor 3, gamma subunit
IPR017423 tRNA (adenine-N(1)-)-methyltransferase, non-catalytic TRM6 subunit

PFAM

PF04189

PRINTS

PIRSF

PIRSF038170

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UJA5

PhosphoSite

PhosphoSite-Q9UJA5

TrEMBL

UniProt Splice Variant

Entrez Gene

51605

UniGene

Hs.128791

RefSeq

NP_057023

HUGO

HGNC:20900

OMIM

CCDS

CCDS13093

HPRD

13027

IMGT

EMBL

AB032979 AF132943 AK000613 AK300812 AL035461 BC001262

GenPept

AAD27718 AAH01262 BAA86467 BAG62468 CAB55274