Homo sapiens Protein: MCM8 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-51965.7 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | MCM8 | ||||||||||||||||||
Protein Name | minichromosome maintenance complex component 8 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000368161 | ||||||||||||||||||
InnateDB Gene | IDBG-51957 (MCM8) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8- MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle. {ECO:0000269PubMed:22771115}. | ||||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000269PubMed:12527764, ECO:0000269PubMed:18072282}. Note=Localizes to nuclear foci and colocalizes with RAD51. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Highest levels in placenta, lung and pancreas. Low levels in skeletal muscle and kidney. Expressed in various tumors with highest levels in colon and lung cancers. {ECO:0000269PubMed:12771218}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000523
Magnesium chelatase, ChlI subunit IPR001208 Mini-chromosome maintenance, DNA-dependent ATPase IPR012340 Nucleic acid-binding, OB-fold IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF01078
PF00493 |
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PRINTS |
PR01657
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PIRSF | |||||||||||||||||||
SMART |
SM00350
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q9UJA3 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q9UJA3 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 84515 | ||||||||||||||||||
UniGene | Hs.721004 | ||||||||||||||||||
RefSeq | NP_001268451 | ||||||||||||||||||
HUGO | HGNC:16147 | ||||||||||||||||||
OMIM | 608187 | ||||||||||||||||||
CCDS | CCDS63226 | ||||||||||||||||||
HPRD | 12186 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AJ439063 AK027644 AK314654 AL035461 AY158211 BC008830 BC080656 BC101054 BC101055 BC101056 BC101057 CH471133 | ||||||||||||||||||
GenPept | AAH08830 AAH80656 AAI01055 AAI01056 AAI01057 AAI01058 AAO21222 BAB55260 BAG37214 CAB55276 CAD27750 CAI23480 EAX10403 EAX10404 | ||||||||||||||||||