Version 5.4
Homo sapiens Protein: TMPO
Summary
InnateDB Protein IDBP-52215.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMPO
Protein Name thymopoietin
Synonyms CMD1T; LAP2; LEMD4; PRO0868; TP;
Species Homo sapiens
Ensembl Protein ENSP00000266732
InnateDB Gene IDBG-52209 (TMPO)
Protein Structure
UniProt Annotation
Function May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
Subcellular Localization Nucleus. Chromosome. Note=Expressed diffusely throughout the nucleus.
Disease Associations Cardiomyopathy, dilated 1T (CMD1T) [MIM:613740]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269PubMed:16247757}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Expressed in many tissues. Most abundant in adult thymus and fetal liver.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 70 [view]
Protein-Protein 65 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005521 lamin binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
Protein Structure and Domains
PDB ID
InterPro IPR003887 LEM domain
IPR011015 LEM/LEM-like domain
IPR013146 LEM-like domain
IPR021623 Lamina-associated polypeptide 2 alpha
PFAM PF03020
PF08198
PF11560
PRINTS
PIRSF
SMART SM00540
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P42166
PhosphoSite PhosphoSite-P42166
TrEMBL
UniProt Splice Variant
Entrez Gene 7112
UniGene Hs.622940
RefSeq NP_003267
HUGO HGNC:11875
OMIM 188380
CCDS CCDS9064
HPRD 01777
IMGT
EMBL S76736 U09086 U18266 U18267 U18268 U18270
GenPept AAB33958 AAB60329 AAB60433

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca