Version 5.4
Homo sapiens Gene: TMPO
Summary
InnateDB Gene IDBG-52209.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMPO
Gene Name thymopoietin
Synonyms CMD1T; LAP2; LEMD4; PRO0868; TP
Species Homo sapiens
Ensembl Gene ENSG00000120802
Encoded Proteins
IDBP-52211
thymopoietin
IDBP-52213
thymopoietin
IDBP-52215
thymopoietin
IDBP-244405
thymopoietin
IDBP-591601
thymopoietin
IDBP-593730
thymopoietin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:98515512-98550379
Strand Forward strand
Band q23.1
Transcripts
ENST00000343315 ENSP00000340251
ENST00000261210 ENSP00000261210
ENST00000266732 ENSP00000266732
ENST00000393053 ENSP00000376773
ENST00000556029 ENSP00000450627
ENST00000548911
ENST00000546828
ENST00000549938
ENST00000552831
ENST00000547214
ENST00000556678 ENSP00000451552
ENST00000548223
ENST00000551987
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 70 [view]
Protein-Protein 65 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005521 lamin binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019961
View Gene Order
ENSBTAG00000004240
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.11355 Hs.609438 Hs.622940
RefSeq NM_001032283 NM_001032284 NM_003276
HUGO
OMIM
CCDS CCDS31879 CCDS31880 CCDS9064
HPRD 01777
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca