InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPINK1

Summary

InnateDB Protein

IDBP-52282.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPINK1

Protein Name

serine peptidase inhibitor, Kazal type 1

Synonyms

PCTT; PSTI; Spink3; TATI; TCP;

Species

Homo sapiens

Ensembl Protein

ENSP00000296695

InnateDB Gene

IDBG-52280 (SPINK1)

Protein Structure

UniProt Annotation

Function

This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas.

Subcellular Localization

Secreted.

Disease Associations

Pancreatitis, hereditary (PCTT) [MIM:167800]: A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks. {ECO:0000269PubMed:10691414, ECO:0000269PubMed:10835640, ECO:0000269PubMed:12974284}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Tropical calcific pancreatitis (TCP) [MIM:608189]: Idiopathic, juvenile, nonalcoholic form of chronic pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus, and an exceptionally high incidence of pancreatic cancer. {ECO:0000269PubMed:12011155, ECO:0000269PubMed:12187509}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004866	endopeptidase inhibitor activity
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0030414	peptidase inhibitor activity

Biological Process

GO:0010466	negative regulation of peptidase activity
GO:0010751	negative regulation of nitric oxide mediated signal transduction
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0060046	regulation of acrosome reaction
GO:0090281	negative regulation of calcium ion import
GO:1900004	negative regulation of serine-type endopeptidase activity
GO:2001256	regulation of store-operated calcium entry