InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SAT1

Summary

InnateDB Protein

IDBP-52304.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SAT1

Protein Name

spermidine/spermine N1-acetyltransferase 1

Synonyms

DC21; KFSD; KFSDX; SAT; SSAT; SSAT-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000368572

InnateDB Gene

IDBG-52302 (SAT1)

Protein Structure

UniProt Annotation

Function

Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine.

Subcellular Localization

Cytoplasm.

Disease Associations

Keratosis follicularis spinulosa decalvans X-linked (KFSDX) [MIM:308800]: A rare disorder affecting the skin and the eye. Affected men show thickening of the skin of the neck, ears, and extremities, especially the palms and soles, loss of eyebrows, eyelashes and beard, thickening of the eyelids with blepharitis and ectropion, and corneal degeneration. {ECO:0000269PubMed:12215835, ECO:0000269PubMed:9341865}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	65 [view]
Protein-Protein	65 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004145	diamine N-acetyltransferase activity
GO:0005515	protein binding
GO:0008080	N-acetyltransferase activity
GO:0019809	spermidine binding

Biological Process

GO:0001525	angiogenesis
GO:0006595	polyamine metabolic process
GO:0006596	polyamine biosynthetic process
GO:0006598	polyamine catabolic process
GO:0009447	putrescine catabolic process
GO:0032918	spermidine acetylation
GO:0034641	cellular nitrogen compound metabolic process
GO:0042127	regulation of cell proliferation
GO:0044281	small molecule metabolic process