Homo sapiens Gene: SAT1
Summary
InnateDB Gene IDBG-52302.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SAT1
Gene Name spermidine/spermine N1-acetyltransferase 1
Synonyms DC21; KFSD; KFSDX; SAT; SSAT; SSAT-1;
Species Homo sapiens
Ensembl Gene ENSG00000130066
Encoded Proteins
spermidine/spermine N1-acetyltransferase 1
spermidine/spermine N1-acetyltransferase 1
spermidine/spermine N1-acetyltransferase 1
spermidine/spermine N1-acetyltransferase 1
spermidine/spermine N1-acetyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:23783158-23786226
Strand Forward strand
Band p22.11
Transcripts
ENST00000379270 ENSP00000368572
ENST00000379254 ENSP00000368556
ENST00000379253 ENSP00000368555
ENST00000379251 ENSP00000368553
ENST00000489394
ENST00000463236
ENST00000487713
ENST00000474223
ENST00000462639
ENST00000612412 ENSP00000483974
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 65 [view]
Protein-Protein 65 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004145 diamine N-acetyltransferase activity
GO:0005515 protein binding
GO:0008080 N-acetyltransferase activity
GO:0019809 spermidine binding
Biological Process
GO:0001525 angiogenesis
GO:0006595 polyamine metabolic process
GO:0006596 polyamine biosynthetic process
GO:0006598 polyamine catabolic process
GO:0008152 metabolic process
GO:0009447 putrescine catabolic process
GO:0032918 spermidine acetylation
GO:0034641 cellular nitrogen compound metabolic process
GO:0042127 regulation of cell proliferation
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of polyamines pathway
Metabolism of amino acids and derivatives pathway
Interconversion of polyamines pathway
Metabolism pathway
KEGG
Arginine and proline metabolism pathway
INOH
Arginine Proline metabolism pathway
PID BIOCARTA
PID NCI
Alpha9 beta1 integrin signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_002970
HUGO
OMIM
CCDS CCDS14207
HPRD 02431
IMGT
EMBL
GenPept
RNA Seq Atlas