InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HAO1

Summary

InnateDB Protein

IDBP-52398.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HAO1

Protein Name

hydroxyacid oxidase (glycolate oxidase) 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000368066

InnateDB Gene

IDBG-52396 (HAO1)

Protein Structure

UniProt Annotation

Function

Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2- hydroxy octanoate. {ECO:0000269PubMed:18215067}.

Subcellular Localization

Peroxisome.

Disease Associations

Tissue Specificity

Liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003973	(S)-2-hydroxy-acid oxidase activity
GO:0005102	receptor binding
GO:0008891	glycolate oxidase activity
GO:0010181	FMN binding
GO:0015930	glutamate synthase activity
GO:0016491	oxidoreductase activity
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors
GO:0047969	glyoxylate oxidase activity
GO:0052852	very-long-chain-(S)-2-hydroxy-acid oxidase activity
GO:0052853	long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity
GO:0052854	medium-chain-(S)-2-hydroxy-acid oxidase activity

Biological Process

GO:0001561	fatty acid alpha-oxidation
GO:0006537	glutamate biosynthetic process
GO:0006979	response to oxidative stress
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0046296	glycolate catabolic process
GO:0046487	glyoxylate metabolic process
GO:0055114	oxidation-reduction process