Homo sapiens Gene: HAO1
Summary
InnateDB Gene IDBG-52396.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HAO1
Gene Name hydroxyacid oxidase (glycolate oxidase) 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101323
Encoded Proteins
hydroxyacid oxidase (glycolate oxidase) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:7882981-7940474
Strand Reverse strand
Band p12.3
Transcripts
ENST00000378789 ENSP00000368066
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003973 (S)-2-hydroxy-acid oxidase activity
GO:0005102 receptor binding
GO:0008891 glycolate oxidase activity
GO:0010181 FMN binding
GO:0015930 glutamate synthase activity
GO:0016491 oxidoreductase activity
GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors
GO:0047969 glyoxylate oxidase activity
GO:0052852 very-long-chain-(S)-2-hydroxy-acid oxidase activity
GO:0052853 long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity
GO:0052854 medium-chain-(S)-2-hydroxy-acid oxidase activity
Biological Process
GO:0001561 fatty acid alpha-oxidation
GO:0006537 glutamate biosynthetic process
GO:0006979 response to oxidative stress
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
GO:0046296 glycolate catabolic process
GO:0046487 glyoxylate metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of amino acids and derivatives pathway
Glyoxylate metabolism pathway
Metabolism pathway
KEGG
Glyoxylate and dicarboxylate metabolism pathway
Peroxisome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9UJM8
TrEMBL A8K058
UniProt Splice Variant
Entrez Gene 54363
UniGene Hs.193640
RefSeq NM_017545
HUGO HGNC:4809
OMIM 605023
CCDS CCDS13100
HPRD 05429
IMGT
EMBL AB024079 AF231916 AF244134 AK289423 AK313839 AL021879 AL121739 BC113665 BC113667 CH471133
GenPept AAF40199 AAF63219 AAI13666 AAI13668 BAA82872 BAF82112 BAG36571 CAB57329 CAC34364 EAX10379 EAX10380
RNA Seq Atlas 54363