InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DTX3L

Summary

InnateDB Protein

IDBP-52648.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DTX3L

Protein Name

deltex 3-like (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000296161

InnateDB Gene

IDBG-52646 (DTX3L)

Protein Structure

UniProt Annotation

Function

Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post- translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1- dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. {ECO:0000269PubMed:12670957, ECO:0000269PubMed:19818714, ECO:0000269PubMed:23230272}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage in a PARP1-dependent manner.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	38 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0042393	histone binding