Version 5.4
Homo sapiens Gene: DTX3L
Summary
InnateDB Gene IDBG-52646.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DTX3L
Gene Name deltex 3-like (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163840
Encoded Proteins
IDBP-52648
deltex 3-like (Drosophila)
IDBP-52650
deltex 3-like (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:122564238-122575203
Strand Forward strand
Band q21.1
Transcripts
ENST00000296161 ENSP00000296161
ENST00000383661 ENSP00000373157
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 40 [view]
Protein-Protein 38 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0042393 histone binding
Biological Process
GO:0006302 double-strand break repair
GO:0006974 cellular response to DNA damage stimulus
GO:0010390 histone monoubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049502
View Gene Order
ENSBTAG00000009933
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04330
Notch signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q8TDB6
TrEMBL
UniProt Splice Variant
Entrez Gene 151636
UniGene Hs.708262
RefSeq NM_138287
HUGO HGNC:30323
OMIM 613143
CCDS CCDS3015
HPRD
IMGT
EMBL AF484416 AK125086 AY225123 AY780792 BC042191 BC060509 CH471052
GenPept AAH42191 AAH60509 AAL90859 AAP57517 AAV98362 BAG54138 EAW79476
RNA Seq Atlas 151636

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca