Homo sapiens Gene: DTX3L
Summary
InnateDB Gene IDBG-52646.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DTX3L
Gene Name deltex 3-like (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163840
Encoded Proteins
deltex 3-like (Drosophila)
deltex 3-like (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:122564238-122575203
Strand Forward strand
Band q21.1
Transcripts
ENST00000296161 ENSP00000296161
ENST00000383661 ENSP00000373157
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 40 [view]
Protein-Protein 38 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0042393 histone binding
Biological Process
GO:0006302 double-strand break repair
GO:0006974 cellular response to DNA damage stimulus
GO:0010390 histone monoubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
Notch signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.708262
RefSeq NM_138287
HUGO
OMIM
CCDS CCDS3015
HPRD 16843
IMGT
EMBL
GenPept
RNA Seq Atlas