InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DUSP3

Summary

InnateDB Protein

IDBP-52947.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUSP3

Protein Name

dual specificity phosphatase 3

Synonyms

VHR;

Species

Homo sapiens

Ensembl Protein

ENSP00000226004

InnateDB Gene

IDBG-52945 (DUSP3)

Protein Structure

UniProt Annotation

Function

Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2. {ECO:0000269PubMed:10224087, ECO:0000269PubMed:11863439}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10224087}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0033549	MAP kinase phosphatase activity

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0001701	in utero embryonic development
GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0043409	negative regulation of MAPK cascade
GO:0045087	innate immune response
GO:0045931	positive regulation of mitotic cell cycle
GO:0046329	negative regulation of JNK cascade
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050860	negative regulation of T cell receptor signaling pathway
GO:0050868	negative regulation of T cell activation
GO:0051403	stress-activated MAPK cascade
GO:0070373	negative regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0001772	immunological synapse
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR020405 Atypical dual specificity phosphatase, subfamily A
IPR020417 Atypical dual specificity phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00782

PRINTS

PR00700
PR01909
PR01908

PIRSF

SMART

SM00194
SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt