Version 5.4
Mus musculus Protein: Cdk5r1
Summary
InnateDB Protein IDBP-531588.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdk5r1
Protein Name cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Synonyms Cdk5r; D11Bwg0379e; p25; p35;
Species Mus musculus
Ensembl Protein ENSMUSP00000120964
InnateDB Gene IDBG-204311 (Cdk5r1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0016534 cyclin-dependent protein kinase 5 activator activity
GO:0019901 protein kinase binding
GO:0045296 cadherin binding
GO:0046875 ephrin receptor binding
Biological Process
GO:0001764 neuron migration
GO:0007049 cell cycle
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway
GO:0009790 embryo development
GO:0018107 peptidyl-threonine phosphorylation
GO:0021549 cerebellum development
GO:0021722 superior olivary nucleus maturation
GO:0021766 hippocampus development
GO:0021819 layer formation in cerebral cortex
GO:0030517 negative regulation of axon extension
GO:0031175 neuron projection development
GO:0033136 serine phosphorylation of STAT3 protein
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0043525 positive regulation of neuron apoptotic process
GO:0045860 positive regulation of protein kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090314 positive regulation of protein targeting to membrane
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex
GO:0030424 axon
GO:0030426 growth cone
GO:0031594 neuromuscular junction
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0043292 contractile fiber
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:101764
InterPro IPR004944 Cyclin-dependent kinase 5 activator
PFAM PF03261
PRINTS
PIRSF PIRSF009324
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL B1AQH0
UniProt Splice Variant
Entrez Gene 12569
UniGene Mm.474282
RefSeq
MGI ID
MGI Symbol Cdk5r1
OMIM
CCDS
HPRD
IMGT
EMBL AL591146
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca