InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Irf1

Summary

InnateDB Protein

IDBP-532223.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Irf1

Protein Name

interferon regulatory factor 1

Synonyms

AU020929; Irf-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000118795

InnateDB Gene

IDBG-172251 (Irf1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 120 interaction(s) predicted by orthology.

Experimentally validated
Total	83 [view]
Protein-Protein	22 [view]
Protein-DNA	61 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	120 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0010468	regulation of gene expression
GO:0043374	CD8-positive, alpha-beta T cell differentiation
GO:0045084	positive regulation of interleukin-12 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:96590

InterPro

IPR001346 Interferon regulatory factor DNA-binding domain

PFAM

PF00605

PRINTS

PR00267

PIRSF

SMART

SM00348

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D6RH71

UniProt Splice Variant

Entrez Gene

16362

UniGene

Mm.399626

RefSeq

MGI ID

MGI Symbol

Irf1

OMIM

CCDS

HPRD

IMGT

EMBL

AL596182

GenPept