Version 5.4
Mus musculus Protein: Sorbs2
Summary
InnateDB Protein IDBP-532265.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sorbs2
Protein Name sorbin and SH3 domain containing 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000116768
InnateDB Gene IDBG-152757 (Sorbs2)
Protein Structure
UniProt Annotation
Function Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Found at the Z line sarcomeres, stress fibers, dense bodies and focal adhesion. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0046872 metal ion binding
Biological Process
GO:0007015 actin filament organization
GO:0007155 cell adhesion
GO:0016477 cell migration
Cellular Component
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0030018 Z disc
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:1924574
InterPro IPR001452 SH3 domain
IPR003127 Sorbin-like
IPR011511 Variant SH3 domain
PFAM PF00018
PF14604
PF02208
PF07653
PRINTS PR00452
PIRSF
SMART SM00326
SM00459
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UTJ2
PhosphoSite PhosphoSite-Q3UTJ2
TrEMBL Z4YJR7
UniProt Splice Variant
Entrez Gene 234214
UniGene Mm.489875
RefSeq XP_006509382
MGI ID
MGI Symbol Sorbs2
OMIM
CCDS
HPRD
IMGT
EMBL AC113469 AC116747 AC116861 AC158351 AK041051 AK049030 AK079130 AK083429 AK122369 AK139388 AK140498 BC039163
GenPept AAH39163 BAC30799 BAC33518 BAC37554 BAC38913 BAC65651 BAE23988 BAE24407

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca