Version 5.4
Mus musculus Gene: Sorbs2
Summary
InnateDB Gene IDBG-152757.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sorbs2
Gene Name sorbin and SH3 domain containing 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000031626
Encoded Proteins
IDBP-152759
sorbin and SH3 domain containing 2
IDBP-152765
sorbin and SH3 domain containing 2
IDBP-537449
sorbin and SH3 domain containing 2
IDBP-534839
sorbin and SH3 domain containing 2
IDBP-533139
sorbin and SH3 domain containing 2
IDBP-539284
sorbin and SH3 domain containing 2
IDBP-539055
sorbin and SH3 domain containing 2
IDBP-538901
sorbin and SH3 domain containing 2
IDBP-541283
sorbin and SH3 domain containing 2
IDBP-536802
sorbin and SH3 domain containing 2
IDBP-533119
sorbin and SH3 domain containing 2
IDBP-542400
sorbin and SH3 domain containing 2
IDBP-531590
sorbin and SH3 domain containing 2
IDBP-537094
sorbin and SH3 domain containing 2
IDBP-536101
sorbin and SH3 domain containing 2
IDBP-532377
sorbin and SH3 domain containing 2
IDBP-533886
sorbin and SH3 domain containing 2
IDBP-532361
sorbin and SH3 domain containing 2
IDBP-532265
sorbin and SH3 domain containing 2
IDBP-535471
sorbin and SH3 domain containing 2
IDBP-536970
sorbin and SH3 domain containing 2
IDBP-532638
sorbin and SH3 domain containing 2
IDBP-619677
sorbin and SH3 domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154556:
Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:45507788-45827906
Strand Forward strand
Band B1.1
Transcripts
ENSMUST00000067107 ENSMUSP00000067641
ENSMUST00000067065 ENSMUSP00000070720
ENSMUST00000124544
ENSMUST00000138049 ENSMUSP00000123503
ENSMUST00000141039 ENSMUSP00000117544
ENSMUST00000134321 ENSMUSP00000115842
ENSMUST00000135336 ENSMUSP00000114286
ENSMUST00000145458 ENSMUSP00000116536
ENSMUST00000127395
ENSMUST00000130850 ENSMUSP00000123195
ENSMUST00000153798 ENSMUSP00000118353
ENSMUST00000134675 ENSMUSP00000118160
ENSMUST00000139869 ENSMUSP00000121235
ENSMUST00000133864
ENSMUST00000126067 ENSMUSP00000118562
ENSMUST00000136119
ENSMUST00000132139 ENSMUSP00000123250
ENSMUST00000143820 ENSMUSP00000119539
ENSMUST00000149752 ENSMUSP00000121073
ENSMUST00000130011 ENSMUSP00000121619
ENSMUST00000150102 ENSMUSP00000114951
ENSMUST00000139103 ENSMUSP00000119380
ENSMUST00000125295 ENSMUSP00000116768
ENSMUST00000132767
ENSMUST00000140088 ENSMUSP00000114158
ENSMUST00000155858 ENSMUSP00000122820
ENSMUST00000132730
ENSMUST00000146627 ENSMUSP00000120487
ENSMUST00000136344
ENSMUST00000156549
ENSMUST00000171337 ENSMUSP00000128000
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0007015 actin filament organization
GO:0007155 cell adhesion
GO:0016477 cell migration
Cellular Component
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0030018 Z disc
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000154556
View Gene Order
ENSBTAG00000016486
Not yet available
Cross-References
SwissProt
TrEMBL D3Z2C7
UniProt Splice Variant
Entrez Gene 234214
UniGene Mm.211096 Mm.408942 Mm.489875
RefSeq NM_001205219 NM_172752 XM_006509362 XM_006509363 XM_006509368 XM_006509371 XM_006509372 XM_006509373 XM_006509379 XM_006509381 XM_006509382 XM_006509383 XM_006509384 XM_006509386
OMIM
CCDS CCDS57618 CCDS57619
HPRD
IMGT
MGI ID MGI:1924574
MGI Symbol Sorbs2
EMBL AC113469 AC116747 AC116861 AC158351
GenPept
RNA Seq Atlas 234214

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca