InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Clu

Summary

InnateDB Protein

IDBP-532306.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clu

Protein Name

clusterin

Synonyms

AI893575; ApoJ; Cli; D14Ucla3; Sgp-2; Sgp2; SP-40; Sugp-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000121633

InnateDB Gene

IDBG-174736 (Clu)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 66 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	66 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0051787	misfolded protein binding

Biological Process

GO:0008219	cell death
GO:0009615	response to virus
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032463	negative regulation of protein homooligomerization
GO:0043065	positive regulation of apoptotic process
GO:0050821	protein stabilization
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051788	response to misfolded protein
GO:0061077	chaperone-mediated protein folding
GO:0097193	intrinsic apoptotic signaling pathway
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005739	mitochondrion
GO:0031012	extracellular matrix
GO:0034366	spherical high-density lipoprotein particle
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:88423

InterPro

IPR000753 Clusterin-like
IPR016014 Clusterin, N-terminal

PFAM

PF01093

PRINTS

PIRSF

SMART

SM00030

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q3V245

UniProt Splice Variant

Entrez Gene

12759

UniGene

RefSeq

MGI ID

MGI Symbol

Clu

OMIM

CCDS

HPRD

IMGT

EMBL

AC126444 AK132030

GenPept

BAE20954