Version 5.4
Mus musculus Protein: Plch1
Summary
InnateDB Protein IDBP-533117.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plch1
Protein Name phospholipase C, eta 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000124463
InnateDB Gene IDBG-148210 (Plch1)
Protein Structure
UniProt Annotation
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269PubMed:15702972}.
Subcellular Localization Cytoplasm. Membrane {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in brain and to a lower extent in lung. In brain, it is found in cerebrum, cerebellum and spinal cord. {ECO:0000269PubMed:15702972}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
GO:0050429 calcium-dependent phospholipase C activity
Biological Process
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0016042 lipid catabolic process
GO:0035556 intracellular signal transduction
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0031965 nuclear membrane
Protein Structure and Domains
PDB ID MGI:2683547
InterPro IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001849 Pleckstrin homology domain
IPR002048 EF-hand domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
PFAM PF00168
PF00388
PF00387
PF00169
PF00036
PF13202
PF13405
PF09279
PRINTS PR00360
PR00390
PIRSF
SMART SM00239
SM00148
SM00149
SM00233
SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q4KWH5
PhosphoSite PhosphoSite-Q4KWH5
TrEMBL
UniProt Splice Variant
Entrez Gene 269437
UniGene Mm.488521
RefSeq NP_001171203
MGI ID
MGI Symbol Plch1
OMIM
CCDS CCDS57215
HPRD
IMGT
EMBL AK173095 AY691172 AY691173 AY691174 BC042549 BC052372 BC055005
GenPept AAH42549 AAH52372 AAH55005 AAW22609 AAW22610 AAW22611 BAD32373

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca