InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hus1

Summary

InnateDB Protein

IDBP-533118.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hus1

Protein Name

Hus1 homolog (S. pombe)

Synonyms

mHus1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000114339

InnateDB Gene

IDBG-149401 (Hus1)

Protein Structure

UniProt Annotation

Function

Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=In discrete nuclear foci upon DNA damage. DNA damage induces its nuclear translocation. Shuttles between the nucleus and the cytoplasm (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:10395797}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0000077	DNA damage checkpoint
GO:0000724	double-strand break repair via homologous recombination
GO:0001932	regulation of protein phosphorylation
GO:0006281	DNA repair
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0007093	mitotic cell cycle checkpoint
GO:0008156	negative regulation of DNA replication
GO:0009411	response to UV
GO:0009790	embryo development
GO:0071479	cellular response to ionizing radiation