Mus musculus Gene: Hus1
Summary
InnateDB Gene IDBG-149401.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hus1
Gene Name Hus1 homolog (S. pombe)
Synonyms mHus1;
Species Mus musculus
Ensembl Gene ENSMUSG00000020413
Encoded Proteins
Hus1 homolog (S. pombe)
Hus1 homolog (S. pombe)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136273:
The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:8993137-9011191
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000020683 ENSMUSP00000020683
ENSMUST00000129115 ENSMUSP00000114339
ENSMUST00000152890
ENSMUST00000139877
ENSMUST00000146002
ENSMUST00000127578
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0000724 double-strand break repair via homologous recombination
GO:0001932 regulation of protein phosphorylation
GO:0006281 DNA repair
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0007093 mitotic cell cycle checkpoint
GO:0008156 negative regulation of DNA replication
GO:0009411 response to UV
GO:0009790 embryo development
GO:0071479 cellular response to ionizing radiation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005794 Golgi apparatus
GO:0030896 checkpoint clamp complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cell Cycle pathway
Cell Cycle Checkpoints pathway
G2/M Checkpoints pathway
Activation of ATR in response to replication stress pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
G2/M Checkpoints pathway
Cell Cycle pathway
Activation of ATR in response to replication stress pathway
Cell Cycle Checkpoints pathway
KEGG
INOH
PID BIOCARTA
Role of brca1 brca2 and atr in cancer susceptibility [Biocarta view]
PID NCI
Fanconi anemia pathway
ATR signaling pathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.42201
RefSeq NM_008316 XM_006514532
OMIM
CCDS CCDS24429
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas