InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hus1

Summary

InnateDB Gene

IDBG-149401.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hus1

Gene Name

Hus1 homolog (S. pombe)

Synonyms

mHus1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020413

Encoded Proteins

IDBP-149403

Hus1 homolog (S. pombe)

IDBP-533118

Hus1 homolog (S. pombe)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136273:
The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:8993137-9011191

Strand

Reverse strand

Band

Transcripts

ENSMUST00000020683	ENSMUSP00000020683
ENSMUST00000129115	ENSMUSP00000114339
ENSMUST00000152890
ENSMUST00000139877
ENSMUST00000146002
ENSMUST00000127578

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000077	DNA damage checkpoint
GO:0000724	double-strand break repair via homologous recombination
GO:0001932	regulation of protein phosphorylation
GO:0006281	DNA repair
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0007093	mitotic cell cycle checkpoint
GO:0008156	negative regulation of DNA replication
GO:0009411	response to UV
GO:0009790	embryo development
GO:0071479	cellular response to ionizing radiation