Version 5.4
Mus musculus Protein: Myc
Summary
InnateDB Protein IDBP-533134.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Myc
Protein Name myelocytomatosis oncogene
Synonyms AU016757; bHLHe39; Myc2; Niard; Nird;
Species Mus musculus
Ensembl Protein ENSMUSP00000125480
InnateDB Gene IDBG-144556 (Myc)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 676 interaction(s) predicted by orthology.
Experimentally validated
Total 65 [view]
Protein-Protein 26 [view]
Protein-DNA 38 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 676 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001783 B cell apoptotic process
GO:0002082 regulation of oxidative phosphorylation
GO:0002904 positive regulation of B cell apoptotic process
GO:0006006 glucose metabolic process
GO:0006352 DNA-templated transcription, initiation
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006848 pyruvate transport
GO:0006865 amino acid transport
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007007 inner mitochondrial membrane organization
GO:0007346 regulation of mitotic cell cycle
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009100 glycoprotein metabolic process
GO:0009314 response to radiation
GO:0009611 response to wounding
GO:0009812 flavonoid metabolic process
GO:0010468 regulation of gene expression
GO:0010918 positive regulation of mitochondrial membrane potential
GO:0016055 Wnt signaling pathway
GO:0016485 protein processing
GO:0019087 transformation of host cell by virus
GO:0021854 hypothalamus development
GO:0032091 negative regulation of protein binding
GO:0032355 response to estradiol
GO:0035914 skeletal muscle cell differentiation
GO:0042474 middle ear morphogenesis
GO:0042981 regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043279 response to alkaloid
GO:0043473 pigmentation
GO:0044330 canonical Wnt signaling pathway involved in positive regulation of wound healing
GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0044337 canonical Wnt signaling pathway involved in positive regulation of apoptotic process
GO:0045023 G0 to G1 transition
GO:0045787 positive regulation of cell cycle
GO:0045821 positive regulation of glycolytic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046325 negative regulation of glucose import
GO:0046722 lactic acid secretion
GO:0048705 skeletal system morphogenesis
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound
GO:0071322 cellular response to carbohydrate stimulus
GO:0071347 cellular response to interleukin-1
GO:0071391 cellular response to estrogen stimulus
GO:0071464 cellular response to hydrostatic pressure
GO:0071966 fungal-type cell wall polysaccharide metabolic process
GO:1901857 positive regulation of cellular respiration
GO:2001171 positive regulation of ATP biosynthetic process
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005819 spindle
GO:0016604 nuclear body
GO:0030424 axon
Protein Structure and Domains
PDB ID MGI:97250
InterPro IPR012682 Transcription regulator Myc, N-terminal
PFAM PF01056
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E0CZD1
UniProt Splice Variant
Entrez Gene 17869
UniGene Mm.2444
RefSeq
MGI ID
MGI Symbol Myc
OMIM
CCDS
HPRD
IMGT
EMBL AC134611
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca