InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ucp2

Summary

InnateDB Protein

IDBP-533811.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ucp2

Protein Name

uncoupling protein 2 (mitochondrial, proton carrier)

Synonyms

Slc25a8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000120967

InnateDB Gene

IDBG-201460 (Ucp2)

Protein Structure

UniProt Annotation

Function

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000269PubMed:21785437}; Multi-pass membrane protein {ECO:0000269PubMed:21785437}.

Disease Associations

Tissue Specificity

Highest in white adipose tissue, also detected in brown adipose tissue, heart and kidney. 4-6 times higher levels are detected in ob/ob and db/db mice.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0000303	response to superoxide
GO:0001666	response to hypoxia
GO:0006839	mitochondrial transport
GO:0007565	female pregnancy
GO:0007568	aging
GO:0009749	response to glucose
GO:0010942	positive regulation of cell death
GO:0032869	cellular response to insulin stimulus
GO:0032870	cellular response to hormone stimulus
GO:0034198	cellular response to amino acid starvation
GO:0043066	negative regulation of apoptotic process
GO:0051881	regulation of mitochondrial membrane potential
GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070542	response to fatty acid
GO:0071333	cellular response to glucose stimulus
GO:0097421	liver regeneration