InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGEF1

Summary

InnateDB Protein

IDBP-53396.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGEF1

Protein Name

Rho guanine nucleotide exchange factor (GEF) 1

Synonyms

GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5;

Species

Homo sapiens

Ensembl Protein

ENSP00000346532

InnateDB Gene

IDBG-53394 (ARHGEF1)

Protein Structure

UniProt Annotation

Function

Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation. {ECO:0000269PubMed:20098430, ECO:0000269PubMed:8810315, ECO:0000269PubMed:9641915, ECO:0000269PubMed:9641916}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10747909}. Membrane {ECO:0000269PubMed:10747909}. Note=Translocated to the membrane by activated GNA13 or LPA stimulation.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:8810315, ECO:0000269PubMed:9135076}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007266	Rho protein signal transduction
GO:0008283	cell proliferation
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050770	regulation of axonogenesis
GO:0050771	negative regulation of axonogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000219 Dbl homology (DH) domain
IPR001849 Pleckstrin homology domain
IPR015212 Regulator of G protein signalling-like domain
IPR016137 Regulator of G protein signalling superfamily

PFAM

PF00621
PF00169
PF09128

PRINTS

PIRSF

SMART

SM00325
SM00233
SM00315

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q92888