Version 5.4
Homo sapiens Gene: ARHGEF1
Summary
InnateDB Gene IDBG-53394.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF1
Gene Name Rho guanine nucleotide exchange factor (GEF) 1
Synonyms GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5
Species Homo sapiens
Ensembl Gene ENSG00000076928
Encoded Proteins
IDBP-53396
Rho guanine nucleotide exchange factor (GEF) 1
IDBP-53398
Rho guanine nucleotide exchange factor (GEF) 1
IDBP-53402
Rho guanine nucleotide exchange factor (GEF) 1
IDBP-53404
Rho guanine nucleotide exchange factor (GEF) 1
IDBP-766124
IDBP-765216
IDBP-763573
IDBP-765619
IDBP-764202
IDBP-766262
IDBP-765480
IDBP-765473
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:41883161-41930150
Strand Forward strand
Band q13.2
Transcripts
ENST00000354532 ENSP00000346532
ENST00000347545 ENSP00000344429
ENST00000337665 ENSP00000337261
ENST00000378152 ENSP00000367394
ENST00000598587
ENST00000595770
ENST00000594044
ENST00000594521 ENSP00000470557
ENST00000598812 ENSP00000473229
ENST00000594258 ENSP00000470042
ENST00000594417 ENSP00000471942
ENST00000596957
ENST00000593609
ENST00000600274
ENST00000595897
ENST00000598444
ENST00000594513
ENST00000600517 ENSP00000469409
ENST00000599846 ENSP00000470715
ENST00000595723 ENSP00000472466
ENST00000600387
ENST00000599589 ENSP00000469735
ENST00000617585
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 33 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007266 Rho protein signal transduction
GO:0008283 cell proliferation
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050770 regulation of axonogenesis
GO:0050771 negative regulation of axonogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040940
View Gene Order
ENSBTAG00000018912
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_13815
Axonal growth inhibition (RHOA activation) pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11061
Signalling by NGF pathway
REACT_13620
p75NTR regulates axonogenesis pathway
REACT_14797
Signaling by GPCR pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
txa2pathway
Thromboxane A2 receptor signaling
lysophospholipid_pathway
LPA receptor mediated events
thrombin_par1_pathway
PAR1-mediated thrombin signaling events
rhoa_reg_pathway
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.631550 Hs.729222
RefSeq NM_004706 NM_198977 NM_199002 XM_005259389
HUGO
OMIM
CCDS CCDS12590 CCDS12591 CCDS12592
HPRD 03511
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca