InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGEF1

Summary

InnateDB Protein

IDBP-53404.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGEF1

Protein Name

Rho guanine nucleotide exchange factor (GEF) 1

Synonyms

GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5;

Species

Homo sapiens

Ensembl Protein

ENSP00000367394

InnateDB Gene

IDBG-53394 (ARHGEF1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity

Biological Process

GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000219 Dbl homology (DH) domain
IPR001849 Pleckstrin homology domain
IPR015212 Regulator of G protein signalling-like domain
IPR016137 Regulator of G protein signalling superfamily

PFAM

PF00621
PF00169
PF09128

PRINTS

PIRSF

SMART

SM00325
SM00233
SM00315

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite