InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BAD

Summary

InnateDB Protein

IDBP-53425.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BAD

Protein Name

BCL2-associated agonist of cell death

Synonyms

BBC2; BCL2L8;

Species

Homo sapiens

Ensembl Protein

ENSP00000309103

InnateDB Gene

IDBG-53423 (BAD)

Protein Structure

UniProt Annotation

Function

Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}.

Subcellular Localization

Mitochondrion outer membrane. Cytoplasm. Note=Upon phosphorylation, locates to the cytoplasm.

Disease Associations

Tissue Specificity

Expressed in a wide variety of tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	61 [view]
Protein-Protein	59 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008289	lipid binding
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019901	protein kinase binding

Biological Process

GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010508	positive regulation of autophagy
GO:0010918	positive regulation of mitochondrial membrane potential
GO:0032024	positive regulation of insulin secretion
GO:0033133	positive regulation of glucokinase activity
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042593	glucose homeostasis
GO:0043065	positive regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044342	type B pancreatic cell proliferation
GO:0045087	innate immune response
GO:0045862	positive regulation of proteolysis
GO:0046031	ADP metabolic process
GO:0046034	ATP metabolic process
GO:0046902	regulation of mitochondrial membrane permeability
GO:0046931	pore complex assembly
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0050679	positive regulation of epithelial cell proliferation
GO:0071260	cellular response to mechanical stimulus
GO:0071316	cellular response to nicotine
GO:0071456	cellular response to hypoxia
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0097190	apoptotic signaling pathway
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097193	intrinsic apoptotic signaling pathway
GO:0097202	activation of cysteine-type endopeptidase activity
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2000078	positive regulation of type B pancreatic cell development
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway