Version 5.4
Mus musculus Protein: Arpc4
Summary
InnateDB Protein IDBP-534454.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arpc4
Protein Name actin related protein 2/3 complex, subunit 4
Synonyms 20kDa; 5330419I20Rik; AI327076; p20-Arc;
Species Mus musculus
Ensembl Protein ENSMUSP00000114839
InnateDB Gene IDBG-254592 (Arpc4)
Protein Structure
UniProt Annotation
Function Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0030674 protein binding, bridging
Biological Process
GO:0008150 biological_process
GO:0030041 actin filament polymerization
GO:0034314 Arp2/3 complex-mediated actin nucleation
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0042995 cell projection
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1915339
InterPro IPR008384 ARP2/3 complex, 20kDa subunit (P20-Arc)
PFAM PF05856
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P59999
PhosphoSite PhosphoSite-P59999
TrEMBL Q3TX55
UniProt Splice Variant
Entrez Gene 68089
UniGene Mm.472172
RefSeq NP_080828
MGI ID
MGI Symbol Arpc4
OMIM
CCDS CCDS20417
HPRD
IMGT
EMBL AJ278129 AK017993 AK039215 AK077325 AK133626 AK136082 AK150690 AK153380 AK159410 AK166440 BC015280
GenPept BAB31026 BAC30279 BAC36751 BAE21755 BAE22810 BAE29769 BAE31946 BAE35061 BAE38777 CAC34583

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca