Version 5.4
Mus musculus Protein: Araf
Summary
InnateDB Protein IDBP-534544.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Araf
Protein Name v-raf murine sarcoma 3611 viral oncogene homolog
Synonyms 1200013E08Rik; A-Raf; Araf1; AW495444;
Species Mus musculus
Ensembl Protein ENSMUSP00000114846
InnateDB Gene IDBG-135379 (Araf)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 44 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0007165 signal transduction
GO:0032006 regulation of TOR signaling
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035556 intracellular signal transduction
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID MGI:88065
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR003116 Raf-like Ras-binding
IPR020454 Diacylglycerol/phorbol-ester binding
IPR029071 Ubiquitin-related domain
PFAM PF00130
PF02196
PRINTS PR00008
PIRSF
SMART SM00109
SM00455
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL B1AUN8
UniProt Splice Variant
Entrez Gene 11836
UniGene Mm.436401
RefSeq
MGI ID
MGI Symbol Araf
OMIM
CCDS
HPRD
IMGT
EMBL AL671885
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca