InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hr

Summary

InnateDB Protein

IDBP-534570.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

hairless

Synonyms

ALUNC; AU; ba; bldy; hr; N; rh; rh-bmh; rhino;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124816

InnateDB Gene

IDBG-178952 (Hr)

Protein Structure

UniProt Annotation

Function

Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Note=Defects in Hr are the cause of a number of pleiotropic effects including structural abnormalities of epithelial cells in the hair follicles, hair loss towards the end of the first hair growth cycle, and the failure of subsequent hair growth cycles. Older mice carrying a hr mutation have been reported to possess altered ratios of T-cell-dependent B-cell responses. Mice homozygous for hr mutation are uniquely sensitive to UV and chemically induced skin tumors.

Tissue Specificity

Expressed predominantly in brain, hair follicles and interfollicular epidermis. No expression in dermis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0045892	negative regulation of transcription, DNA-templated
GO:0055114	oxidation-reduction process

Cellular Component

GO:0016604

nuclear body

Protein Structure and Domains

PDB ID

MGI:96223

InterPro

IPR003347 JmjC domain

PFAM

PF02373
PF08007

PRINTS

PIRSF

SMART

SM00558

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61645

PhosphoSite

PhosphoSite-Q61645

TrEMBL

UniProt Splice Variant

Entrez Gene

15460

UniGene

Mm.7598

RefSeq

MGI ID

MGI Symbol

OMIM

CCDS

CCDS27257

HPRD

IMGT

EMBL

BC049182 Z32675

GenPept

AAH49182 CAA83587