Version 5.4
Mus musculus Protein: Fbxl12
Summary
InnateDB Protein IDBP-534595.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbxl12
Protein Name F-box and leucine-rich repeat protein 12
Synonyms 3110048D16Rik; Fbl12;
Species Mus musculus
Ensembl Protein ENSMUSP00000115058
InnateDB Gene IDBG-137299 (Fbxl12)
Protein Structure
UniProt Annotation
Function Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1354738
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9EPX5
PhosphoSite PhosphoSite-
TrEMBL D3YY70
UniProt Splice Variant
Entrez Gene 30843
UniGene Mm.489685
RefSeq NP_001273459
MGI ID
MGI Symbol Fbxl12
OMIM
CCDS CCDS22881
HPRD
IMGT
EMBL AC164565 AF176525 AF313405 AK011081 AK029429 AK030910 AK137282 BC005699 BC054471
GenPept AAF09134 AAG37272 AAH05699 AAH54471 BAB27385 BAC26448 BAC27180 BAE23292

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca