InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ercc2

Summary

InnateDB Protein

IDBP-535474.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ercc2

Protein Name

excision repair cross-complementing rodent repair deficiency, complementation group 2

Synonyms

AA407812; AU020867; AW240756; CXPD; Ercc-2; XPD;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000117840

InnateDB Gene

IDBG-150400 (Ercc2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

Biological Process

GO:0006139

nucleobase-containing compound metabolic process

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:95413

InterPro

IPR000330 SNF2-related
IPR006554 Helicase-like, DEXD box c2 type
IPR006555 ATP-dependent helicase, C-terminal
IPR010614 DEAD2
IPR010643 Domain of unknown function DUF1227
IPR013020 DNA helicase (DNA repair), Rad3 type
IPR014013 Helicase, superfamily 1/2, ATP-binding domain, DinG/Rad3-type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00176
PF13307
PF06733
PF06777

PRINTS

PIRSF

SMART

SM00488
SM00491

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

13871

UniGene

RefSeq

MGI ID

MGI Symbol

Ercc2

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept