|
InnateDB Protein
|
IDBP-535576.4
|
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
|
Gene Symbol
|
Ssh2
|
|
Protein Name
|
slingshot homolog 2 (Drosophila)
|
|
Synonyms
|
|
|
Species
|
Mus musculus
|
|
Ensembl Protein
|
ENSMUSP00000119681
|
|
InnateDB Gene
|
IDBG-201408 (Ssh2)
|
|
Protein Structure
|
|
| Function |
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269PubMed:14531860}.
|
| Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000269PubMed:14531860}. Cell junction, focal adhesion {ECO:0000269PubMed:14531860}. Note=Colocalizes with filamentous actin in the cytoplasm and the cell periphery. Also localizes to focal adhesions.
|
| Disease Associations |
|
| Tissue Specificity |
Expressed in brain, heart, liver, skeletal muscle, testis and thymus. Also expressed at lower levels in kidney, small intestine and spleen. {ECO:0000269PubMed:14531860}.
|
| Comments |
|
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
|
|
| Predicted by orthology |
| Total |
1 [view]
|
|
|
| PDB ID |
MGI:2679255
|
| InterPro |
|
| PFAM |
|
| PRINTS |
|
| PIRSF |
|
| SMART |
|
| TIGRFAMs |
|
| Modification |
|
| SwissProt |
|
| PhosphoSite |
PhosphoSite-Q5SW75
|
| TrEMBL |
|
| UniProt Splice Variant |
|
| Entrez Gene |
237860
|
| UniGene |
Mm.475485
|
| RefSeq |
|
| MGI ID |
|
| MGI Symbol |
Ssh2
|
| OMIM |
|
| CCDS |
|
| HPRD |
|
| IMGT |
|
| EMBL |
|
| GenPept |
|
|
|
|
Version 5.4