InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Numb

Summary

InnateDB Protein

IDBP-535869.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Numb

Protein Name

numb gene homolog (Drosophila)

Synonyms

Nb;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000122597

InnateDB Gene

IDBG-155803 (Numb)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	1 [view]

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0045294	alpha-catenin binding
GO:0045296	cadherin binding

Biological Process

GO:0007399	nervous system development
GO:0007405	neuroblast proliferation
GO:0007409	axonogenesis
GO:0030862	positive regulation of polarized epithelial cell differentiation
GO:0030900	forebrain development
GO:0034332	adherens junction organization
GO:0045746	negative regulation of Notch signaling pathway
GO:0060487	lung epithelial cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0016323	basolateral plasma membrane
GO:0019897	extrinsic component of plasma membrane
GO:0045177	apical part of cell

Protein Structure and Domains

PDB ID

MGI:107423

InterPro

IPR006020 PTB/PI domain
IPR013625 Tensin phosphotyrosine-binding domain

PFAM

PF00640
PF14719
PF08416

PRINTS

PIRSF

SMART

SM00462

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3Z549

UniProt Splice Variant

Entrez Gene

18222

UniGene

RefSeq

MGI ID

MGI Symbol

Numb

OMIM

CCDS

HPRD

IMGT

EMBL

AC132954 AC133183

GenPept